Back
#1
14.2%
Top 0.8%
14.2%
Top 0.6%
11.5%
Top 0.4%
8.7%
Top 22%
5.4%
Top 4%
3.7%
Top 68%
3.7%
Top 2%
3.7%
Top 0.7%
2.7%
Top 5%
2.7%
Top 90%
2.7%
Top 6%
1.9%
Top 1%
1.9%
Top 2%
1.9%
Top 7%
1.8%
Top 2%
1.5%
Top 5%
1.5%
Top 0.5%
1.5%
Top 1%
1.5%
Top 4%
1.3%
Top 9%
0.9%
Top 21%
0.7%
Top 5%
0.7%
Top 5%
0.7%
Top 4%
0.7%
Top 57%
0.7%
The pleiotropic architecture of human impulsivity across biological scales
2023-11-29
psychiatry and clinical psychology
Title + abstract only
View on medRxiv
Show abstract
Impulsivity is a complex psychological construct that represents a core feature of many psychiatric and neurological conditions. Here, we used multivariate methods to formally model the genetic architecture of impulsivity in humans, advancing genomic discovery and revealing pervasive pleiotropy that largely counters theories of impulsivity as a unitary construct. We identified 18 loci and 93 genes with diverse effects in GWAS and TWAS analyses, respectively, including a hotspot at 17q21.31 that ...
Predicted journal destinations
1
Biological Psychiatry
36 training papers
2
Translational Psychiatry
94 training papers
3
Molecular Psychiatry
84 training papers
4
Psychological Medicine
52 training papers
5
Nature Communications
483 training papers
6
Journal of Affective Disorders
72 training papers
7
Scientific Reports
701 training papers
8
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
27 training papers
9
Biological Psychiatry Global Open Science
23 training papers
10
Frontiers in Psychiatry
56 training papers
11
PLOS ONE
1737 training papers
12
NeuroImage: Clinical
77 training papers
13
Schizophrenia Bulletin
21 training papers
14
Neuropsychopharmacology
29 training papers
15
Nature Genetics
72 training papers
16
Brain, Behavior, and Immunity
35 training papers
17
Psychiatry Research
33 training papers
18
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
15 training papers
19
Journal of Child Psychology and Psychiatry
18 training papers
20
Journal of Psychiatric Research
22 training papers
21
Human Brain Mapping
53 training papers
22
Proceedings of the National Academy of Sciences
100 training papers
23
BJPsych Open
24 training papers
24
The British Journal of Psychiatry
21 training papers
25
Neuroscience & Biobehavioral Reviews
19 training papers
26
eLife
262 training papers