Generating the sigmoid form in neuroscience: A threshold-crossing model
Auty, A. R.
Show abstract
The conventional interpretation1 of a logistic curve in biology is that it indicates the presence of an infection-like mechanism bounded by a saturation limit e.g. saturation occurs when the whole population has been infected. However, a logistic form may be generated by the fluctuating approach of biological systems to, and then exceeding, an effect threshold. The commonly observed trends in frequency and degree of cognitive loss in neurodegenerative disease (NDD) are consistent with a threshold-crossing model. Whereas direct evidence of real life NDD being driven by an infection-like mechanism remains elusive2,3. Variation in susceptibility to NDD may be explained by variation in the rate of biological ageing (e.g. neurodegeneration rate, or, metabolic interference), height of threshold and initial reserve. Each is potentially modifiable and clinically informative.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Examining heterogeneity in dementia using data-driven unsupervised clustering of cognitive profiles 91%
- Relationship between finger movement characteristics and voxel-based specific regional analysis systems for Alzheimer’s disease 91%
- Olfactory Response as a Marker for Alzheimer's Disease: Evidence from Perceptual and Frontal Oscillation Coherence Deficit 91%
Similar papers in this journal
- Selecting the most important self-assessed features for predicting conversion to Mild Cognitive Impairment with Random Forest and Permutation-based methods 93%
- Influence Of Energy Deficiency On The Molecular Processes Of Substantia Nigra Pars Compacta Cell For Understanding Parkinsonian Neurodegeneration: A Comprehensive Biophysical Computational Model 92%
- Hypergraph Clustering for Analyzing Chronic Disease Patterns in Mild Cognitive Impairment Reversion and Progression 92%
Similar papers in this journal
- The PREVENT Dementia programme: Baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia 90%
- Self- versus caregiver-reported apathy across neurological disorders 90%
- White matter microstructure in Parkinson’s disease with and without elevated REM sleep muscle tone 89%
Similar papers in this journal
- Phenotyping Neuropsychiatric Symptoms Profiles of Alzheimer's Disease Using Cluster Analysis on EEG Power 91%
- Detection of cognitive decline using a single-channel EEG with an interactive assessment tool 91%
- Dropout in Neural Networks Simulates theParadoxical Effects of Deep Brain Stimulation onMemory 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.