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Initial clinical evidence on biperiden as antiepileptogenic after traumatic brain injury. A Randomized Clinical Trial

Foresti, M. L.; Garzon, E.; de Moraes, M. T.; Valeriano, R. P.; Santiago, J. P.; dos Santos, G. M.; Longo, N. M.; Baise, C.; Andrade, J. C.; Susemihl, M. A.; Naffah Mazzacoratti, M. d. G.; Paiva, W. S.; Andrade, A. F.; Jacobsen, M.; Mello, L. E.

2023-11-11 neurology
10.1101/2023.11.10.23298341 medRxiv
Show abstract

There is currently no available drug to prevent the development of post-traumatic epilepsy. insufficient evidence regarding the effect of biperiden in preventing post-traumatic epilepsy after TBI. The combined effect of variables known to have an impact on the likelihood of developing late post-traumatic seizures and its unbalanced frequency in the different groups is an aspect to be considered and underpins the need for larger studies. HighlightsPrior research suggests anticholinergics may prevent post-traumatic epilepsy There was insufficient evidence on biperidens role in preventing PTE after TBI Variable impact on post-traumatic epilepsy underscores need for broader studies Graphical Abstract O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=115 SRC="FIGDIR/small/23298341v1_ufig1.gif" ALT="Figure 1"> View larger version (72K): org.highwire.dtl.DTLVardef@1f816a4org.highwire.dtl.DTLVardef@969c42org.highwire.dtl.DTLVardef@1eccc07org.highwire.dtl.DTLVardef@146e5ae_HPS_FORMAT_FIGEXP M_FIG C_FIG

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The top 5 journals account for 50% of the predicted probability mass.

1
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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.