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Leveraging large-scale multi-omics to identify therapeutic targets from genome-wide association studies

2023-11-01 genetic and genomic medicine Title + abstract only
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BACKGROUND: Therapeutic targets supported by genetic evidence from genome-wide association studies (GWAS) show higher probability of success in clinical trials. GWAS is a powerful approach to identify links between genetic variants and phenotypic variation; however, identifying the genes driving associations identified in GWAS remains challenging. Integration of molecular quantitative trait loci (molQTL) such as expression QTL (eQTL) using mendelian randomization (MR) and colocalization analyses...

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