Landscaping of Urine Proteome: Unlocking Diagnostic Potential and Overcoming Unique Challenges
Budnik, B.; Amirkhani, H.; Weinberger, K.; Sargsyan, K.; Forouzanfar, M. H.; Afshin, A.
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This study explores the application of deep proteomic profiling to extract disease-specific features from urine. Early detection of cancer and other chronic disorders is crucial for better outcomes, but traditional diagnostics as well as emerging genomic-based diagnostics are expensive and invasive. Our research reveals that a select group of urinary proteins can accurately detect early-stage diseases with high sensitivity, surpassing current tests. While urine-based protein panels could offer cost-effective and accurate alternatives to current screening methods, kidney factors and blood urine barrier pathologies could pose significant challenges. New diagnostic technologies may emerge because of these findings, ushering in an era of early detection for cancer and chronic diseases. One-Sentence SummaryUrine-based protein panels show distinct patterns in early disease detection, promising opportunities for advancing diagnostic tests
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