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Allostatic load in early adolescence: gene / environment contributions and relevance for mental health
2023-10-28
pediatrics
Title + abstract only
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BackgroundAllostatic load is the cumulative "wear and tear" on the body due to chronic adversity. We aimed to test poly-environmental (exposomic) and polygenic contributions to allostatic load and their combined contribution to early adolescent mental health. MethodsWe analyzed data on N = 5,035 diverse youth (mean age 12) from the Adolescent Brain Cognitive Development Study (ABCD). Using dimensionality reduction method, we calculated and overall allostatic load score (AL) using body mass inde...
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