Rapid activation of IL-2 receptor signaling by CD301b+DC-derived IL-2 dictates the outcome of helper T cell differentiation
Tatsumi, N.; El-Fenej, J.; Davila-Pagan, A.; Kumamoto, Y.
Show abstract
Effector T helper (Th) cell differentiation is fundamental to functional adaptive immunity. Different subsets of dendritic cells (DCs) preferentially induce different types of Th cells, but the fate instruction mechanism for Th type 2 (Th2) differentiation remains enigmatic, as the critical DC-derived cue has not been clearly identified. Here, we show that CD301b+ DCs, a major Th2-inducing DC subset, drive Th2 differentiation through cognate interaction by kick-starting IL-2 receptor signaling in CD4T cells. Mechanistically, CD40 engagement induces IL-2 production selectively from CD301b+ DCs to maximize CD25 expression in CD4 T cells, which is required specifically for the Th2 fate decision. On the other hand, CD25 in CD301b+ DCs facilitates directed action of IL-2 toward cognate CD4T cells. Furthermore, CD301b+ DC-derived IL-2 skews CD4T cells away from the T follicular helper fate. These results highlight the critical role of DC-intrinsic CD40-IL-2 axis in bifurcation of Th cell fate.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling 97%
- Transcriptome and Chromatin Landscape of iNKT cells are Shaped by Subset Differentiation and Antigen Exposure 97%
- Integration of Avidity and Differentiation is enabled by CD8+ T-cell sensing of IFN-γ 96%
Similar papers in this journal
Similar papers in this journal
- Factors that influence the thymic selection of CD8αα intraepithelial lymphocytes 96%
- Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling 95%
- Regulatory T cells control the dynamic and site-specific polarization of CD4 T cells following Salmonella infection 95%
Similar papers in this journal
- Optimal CXCR5 Expression during Tfh Maturation Involves the Bhlhe40-Pou2af1 Axis 97%
- The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state and its deletion improves checkpoint blockade 96%
- An essential role for miR-15/16 in Treg suppression and restriction of proliferation 95%
Similar papers in this journal
- CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells 97%
- SLAM/SAP signaling regulates discrete γδ T cell developmental checkpoints and shapes the innate-like γδ TCR repertoire 96%
- Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.