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Probing different conformational states of polar organizing protein Z with AlphaFold

Taneja, I.; Lasker, K.

2023-10-12 biophysics
10.1101/2023.10.11.561952 bioRxiv
Show abstract

AlphaFold has been a remarkably powerful tool to predict the structures of proteins. Here, we demonstrate that AlphaFold is capable of sampling different conformational states of the oligomerization domain of polar organizing protein Z (PopZ). More broadly, our work suggests that conformational heterogeneity can be extracted from AlphaFold without directly modifying the input multiple sequence alignment.

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