Bacteroides is increased in an autism cohort and induces autism-relevant behavioral changes in mice in a sex-dependent manner
Carmel, J.; Ghanayem, N.; Maayouf, R.; Saleev, N.; Chaterjee, I.; Getselter, D.; Tiknonov, E.; Turjeman, S.; Shaalan, M.; Khatib, S.; Kuzminsky, A.; Kvetniy- Ferdman, N.; Kronos, T.; Bretler, T.; Koren, O.; Elliott, E.
Show abstract
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition which is defined by decreased social communication and the presence of repetitive or stereotypic behaviors. Recent evidence has suggested that the gut-brain axis may be important in neurodevelopment in general and may play a role in ASD in particular. Here, we present a study of the gut microbiome in 96 individuals diagnosed with ASD in Israel, compared to 42 neurotypical individuals. We determined differences in alpha and beta diversity in the microbiome of individuals with ASD and demonstrated that the phylum Bacteroidetes and genus Bacteroides were the most significantly over-represented in individuals with ASD. To understand the possible functional significance of these changes, we treated newborn mice with Bacteroides fragilis at birth. B. fragilis-treated male mice displayed social behavior dysfunction, increased repetitive behaviors and gene expression dysregulation in the prefrontal cortex, while female mice did not display behavioral deficits. These findings suggest that overabundance of Bacteroides, particularly in early life, may have functional consequences for individuals with ASD.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Expression changes in immune and epigenetic gene pathways associated with nutritional metabolites in maternal blood from pregnancies resulting in autism and atypical neurodevelopment 93%
- Maternal antibodies to gliadin and autism spectrum disorders in offspring - A population-based case-control study in Sweden 92%
- Interval Timing is altered in male Nrxn1+/- mice: A Model of Autism Spectrum Disorder 91%
Similar papers in this journal
- Cannabidiol treatment is associated with broadband spectral electrophysiological changes and improved cognition in boys with low-functioning autism spectrum disorder 92%
- Rapid effects of valproic acid on the fetal brain transcriptome: Implications for brain development and autism 92%
- Comorbidities in autism spectrum disorder and their etiologies 92%
Similar papers in this journal
- A meta-analysis of two high-risk prospective cohort studies reveals autism-specific transcriptional changes to chromatin, autoimmune, and environmental response genes in umbilical cord blood 93%
- Hyperthermia elevates brain temperature and improves behavioural signs in animal models of Autism spectrum disorder. 92%
- Neuroanatomy and Behaviour in Mice with a Haploinsufficiency of AT-Rich Interactive Domain 1B (ARID1B) Throughout Development 92%
Similar papers in this journal
- Assessment of infant outgrowth of cow's milk allergy in relation to the faecal microbiome and metaproteome 90%
- Multiple nutritional and gut microbial factors associated with allergic rhinitis: the Hitachi Health Study 90%
- Valproic acid exposure affects social visual lateralization and asymmetric gene expression in zebrafish larvae 90%
Similar papers in this journal
- Sex-specific behavioral features of juvenile and adult haploinsufficient Scn2a+/- female mice, model of Autism Spectrum Disorder 92%
- The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice 91%
- Mouse Model Systems of Autism Spectrum Disorder: Replicability and Informatics Signature 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.