Viral-mediated expression of Erk2 in the nucleus accumbens regulates responses to rewarding and aversive stimuli.
Parise, L. F.; Iniguez, S. D.; Warren, B. L.; Parise, E. M.; Bachtell, R.; Dietz, D.; Nestler, E. J.; Bolanos-Guzman, C.
Show abstract
Second-messenger signaling within the mesolimbic reward circuit is involved in both the long-lived effects of stress and in the underlying mechanisms that promote drug abuse liability. To determine the direct role of kinase signaling within the nucleus accumbens, specifically mitogen-activated protein kinase 1 (ERK2), in mood- and drug-related behavior, we used a herpes-simplex virus to up- or down-regulate ERK2 in adult male rats. We then exposed rats to a battery of behavioral tasks including the elevated plus-maze, open field test, forced-swim test, conditioned place preference, and finally cocaine self-administration. Herein, we show that viral overexpression or knockdown of ERK2 in the nucleus accumbens induces distinct behavioral phenotypes. Specifically, over expression of ERK2 facilitated depression- and anxiety-like behavior while also increasing sensitivity to cocaine. Conversely, down-regulation of ERK2 attenuated behavioral deficits, while blunting sensitivity to cocaine. Taken together, these data implicate ERK2 signaling, within the nucleus accumbens, in the regulation of affective behaviors and modulating sensitivity to the rewarding properties of cocaine.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Disrupted Maternal Behavior in Morphine-Dependent Pregnant Rats and Anhedonia in their Offspring 96%
- Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior 96%
- Domain-selective BET inhibition attenuates transcriptional and behavioral responses to cocaine 96%
Similar papers in this journal
- Ceftriaxone and mGlu2/3 interactions in the nucleus accumbens core affect the reinstatement of cocaine-seeking in male and female rats 96%
- C57 and DBA mouse strains express distinct cocaine avoidance phenotypes in an operant runway independent of differences in striatal dynorphin-enkephalin balance 96%
- Cannabidiol (CBD) potentiates physiological and behavioral markers of hypothalamic-pituitary-adrenal (HPA) axis responsivity in female and male mice 96%
Similar papers in this journal
- Role of mesolimbic cannabinoid receptor 1 in stress-driven increases in cocaine self-administration in male rats 96%
- Prophylactic efficacy of 5-HT4R agonists against stress 95%
- Disentangling the effects of Corticotrophin Releasing Factor and GABA release from the ventral bed nucleus of the stria terminalis on ethanol self-administration in mice 95%
Similar papers in this journal
- Ketamine blocks morphine-induced conditioned place preference and anxiety-like behaviors in mice. 97%
- Forced Abstinence from Alcohol Induces Sex-Specific Depression-like Behavioral and Neural Adaptations in Somatostatin Neurons in Cortical and Amygdalar Regions 96%
- Basolateral amygdala to nucleus accumbens projections differentially mediate flexibility of sign- and goal-tracking rats 95%
Similar papers in this journal
- Effects of dopamine receptor antagonism and amphetamine-induced psychomotor sensitization on sign- and goal-tracking after extended training 96%
- Inactivation of posterior but not anterior dorsomedial caudate-putamen impedes learning with self-administered nicotine stimulus 95%
- Activation of VTA GABA Neurons Disrupts Reward Seeking by Altering Temporal Processing 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.