Investigating markers of pulmonary aspiration in bronchoalveolar lavage from children with severe neurodisability
Maher, R. E.; Trinick, R. E.; Dalzell, M.; Beynon, R. J.; McNamara, P. S.
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Respiratory exacerbations are a frequent cause of hospitalisation in children with severe neurodisability (ND). Direct aspiration of food/saliva, reflux aspiration of gastric contents or a combination of both is thought to be a common cause of respiratory symptoms and disease, particularly when this occurs silently. A number of aspiration biomarkers, including bile acids and pepsin, have been proposed, however, no gold-standard diagnostic tests are currently available. In children with severe ND at high risk of both direct and reflux aspiration, we analysed lower airway samples for saliva- and/or gastric-specific proteins with biomarker potential.
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