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Rolling 2D Bioelectronic film into 1D: a Suturable Long-term Implantable Soft Microfiber

Xie, R.; Yu, Q.; Li, D.; Han, X.; Xu, X.; Huang, J.; Yan, W.; Zhou, X.; Deng, X.; Tian, Q.; Li, Q.; Li, H.; Zheng, H.; Li, G.; Han, F.; Xu, T.; Liu, Z.

2023-11-01 neuroscience
10.1101/2023.10.02.560392 bioRxiv
Show abstract

Long-term implantable bioelectronics can efficiently evaluate the function of the nervous system. 1D fiber-shaped devices require small surgical incisions significantly benefiting long-term biocompatibility. We report a strategy of rolling to reduce the dimension of bioelectronic devices from 2D film to 1D microfiber. The soft and stretchable multifunctional microfiber accommodates more than 60-channel longitudinally-distributed electrodes for bio-electric and -mechanical monitoring. It can be sutured into muscle with tiny incision for 8-month bio-electrical monitoring in rats. Importantly, after 13-month implantation, the fibroblast encapsulation around the fiber is negligible. Moreover, it can wander inside a brain under magnetic field. This strategy not only opens up the study of multi-channel and -function soft and stretchable fiber-shaped sensors but offers a platform for minimally-invasive implantable bioelectronics. One-Sentence SummaryThe rolling enables stretchable electrode array along one single microfiber and multimodal long-term in-vivo monitoring.

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