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The neuronal chromatin landscape in adult schizophrenia brains is linked to early fetal development
2023-10-03
psychiatry and clinical psychology
Title + abstract only
View on medRxiv
Show abstract
Non-coding variants increase risk of neuropsychiatric disease. However, our understanding of the cell-type specific role of the non-coding genome in disease is incomplete. We performed population scale (N=1,393) chromatin accessibility profiling of neurons and non-neurons from two neocortical brain regions: the anterior cingulate cortex and dorsolateral prefrontal cortex. Across both regions, we observed notable differences in neuronal chromatin accessibility between schizophrenia cases and cont...
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