Discovery of essential kinetoplastid-insect adhesion proteins and their function in Leishmania-sand fly interactions
Yanase, R.; Pruzinova, K.; Rea, E.; Moreira-Leite, F.; Taniguchi, A.; Nonaka, S.; Sadlova, J.; Vojtkova, B.; Volf, P.; Sunter, J.
Show abstract
Leishmania species, members of the kinetoplastid parasites, cause leishmaniasis, a neglected tropical disease, in millions of people worldwide1. Leishmania has a complex life cycle with multiple developmental forms, as it cycles between a sand fly vector and a mammalian host; understanding their life cycle is critical to understanding disease spread2. One of the key life cycle stages is the haptomonad form, which is attached to the insect through its flagellum. This adhesion, which is conserved across kinetoplastid parasites, is implicated to have an important function within their life cycles and hence on disease transmission3-5. Here, we discovered kinetoplastid-insect adhesion proteins (KIAPs), which are localised in the attached haptomonad flagellum. Deletion of these KIAPs impaired cell adhesion in vitro and prevented Leishmania from colonising the stomodeal valve in the sand fly, without affecting cell growth. This result will provide important insights for a comprehensive understanding of the Leishmania life cycle.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Inducible nitric oxide synthase (iNOS) is necessary for GBP-mediated T. gondii restriction in murine macrophages via vacuole nitration and intravacuolar network collapse 95%
- Distributed control of motor circuits for backward walking in Drosophila 95%
- Mechanisms of life cycle simplification in African trypanosomes 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.