Assessing the role of mitonuclear interactions on mitochondrial function and organismal fitness in natural Drosophila populations
Bettinazzi, S.; Liang, J.; Rodriguez, E.; Bonneau, M.; Holt, R.; Whitehead, B.; Dowling, D.; Lane, N.; Camus, F.
Show abstract
Mitochondrial metabolism is regulated by a series of enzyme complexes, whose function depends on effective interactions between proteins and RNA encoded by the mitochondrial and nuclear genomes. These epistatic interactions are in turn highly sensitive to the environment. Many studies have found that mitochondrial haplotype frequencies of various taxa associate with latitude or altitude, leading to the hypothesis that mitochondrial genomes may respond to thermal selection and contribute to local adaptation. We used a Drosophila melanogaster panel comprising native (coadapted) populations from the extremes of the Australian east-coast cline, and generated mitonuclear cybrid populations. Our results indicate a strong phenotypic impact of mitonuclear interactions in cybrid lines, involving an apparent trade-off between aerobic capacity and key fitness aspects such as reproduction, growth, and survival. Overall, our study shows that naturally-occurring mitonuclear disruptions can have a meaningful impact on phenotypes, potentially influencing future ecological adaptation and population persistence.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Experimental sexual selection affects the evolution of physiological and life history traits 95%
- A rapidly evolved shift in life history timing during ecological speciation is driven by the transition between developmental phases 94%
- Mitochondrial background can explain variable costs of immune deployment 93%
Similar papers in this journal
Similar papers in this journal
- Evolution of compound eye morphology underlies differences in vision between closely related Drosophila species 93%
- The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors 92%
- Interspecies variation of larval locomotion kinematics in the genus Drosophila and its relation to habitat temperature 92%
Similar papers in this journal
- Evolution of a novel female reproductive strategy in Drosophila melanogaster populations subjected to long term protein restriction 94%
- Testing evolutionary explanations for the lifespan benefit of dietary restriction in Drosophila melanogaster 94%
- Testing the adaptive value of sporulation in budding yeast using experimental evolution 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.