The MUC19 gene in Denisovans, Neanderthals, and Modern Humans: An Evolutionary History of Recurrent Introgression and Natural Selection
Villanea, F. A.; Peede, D.; Kaufman, E. J.; Anorve-Garibay, V.; Dillon, K. E. W.; Zeloni, R.; Marnetto, d.; Moorjani, P.; Jay, F.; Valdmanis, P. N.; Avila-Arcos, M. C.; Huerta-Sanchez, E.
Show abstract
We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants for the Denisovan-like MUC19 haplotype at high frequencies in admixed Latin American individuals, and at highest frequency in 23 ancient Indigenous American individuals, all predating population admixture with Europeans and Africans. We find that the Denisovan-like MUC19 haplotype is under positive selection and carries a higher copy number of a 30 base-pair variable number tandem repeat, and that copy numbers of this repeat are exceedingly high in American populations. Finally, some Neanderthals carry the Denisovan-like MUC19 haplotype, and that it was likely introgressed into human populations through Neanderthal introgression rather than Denisovan introgression. One-Sentence SummaryModern humans and Neanderthals carry a Denisovan variant of the MUC19 gene, which is under positive selection in populations of Indigenous American ancestry.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Mapping gene flow between ancient hominins through demography-aware inference of the ancestral recombination graph 95%
- Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome 95%
- A signature of Neanderthal introgression on molecular mechanisms of environmental responses 95%
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.