Opiate anticipation,opiate induced anatomical changes in hypocretin (Hcrt, orexin) neurons and opiate induced microglial activation are blocked by the dual Hcrt receptor antagonist suvorexant, while opiate analgesia is maintained
McGregor, R.; Wu, M.-F.; Thannickal, T.; Siegel, J.
Show abstract
We previously found that heroin addiction in humans is accompanied by an increase in the number of detected Hcrt neurons and a decrease in their soma size. We now show that the increased number of Hcrt cells visible after morphine treatment is likely the result of increased Hcrt production in neurons having sub-detection levels of the peptides. We find that morphine increases Hcrt projections to the ventral tegmental area (VTA), the level of tyrosine hydroxylase enzyme (TH) and the number of TH positive cells in VTA, with no changes in the adjacent substantia nigra. We find that the dual Hcrt receptor antagonist suvorexant prevents morphine-induced changes in the number and size of Hcrt neurons, microglial activation and morphine anticipatory behavior, but does not diminish morphine analgesia. These findings suggest that combined administration of opiates and suvorexant may be a less addictive way of administering opiates for pain relief in humans.
Matching journals
The top 10 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Cell-type specific expression and behavioral impact of galanin and GalR1 in the locus coeruleus during opioid withdrawal 95%
- Bidirectional sex-dependent regulation of α6 and β3 nicotinic acetylcholine receptors by protein kinase Cε 95%
- Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes 94%
Similar papers in this journal
- Activation of VTA GABA Neurons Disrupts Reward Seeking by Altering Temporal Processing 95%
- Effects of L-Dopa, SKF-38393, and Quinpirole on exploratory, anxiety- and depressive-like behaviors in pubertal female and male mice 94%
- Effects of the selective dopamine D3 receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice 94%
Similar papers in this journal
- Divergent profiles of fentanyl withdrawal and associated pain in mice and rats 95%
- Dysregulation of Kappa Opioid Receptor Neuromodulation of Lateral Habenula Synaptic Function following a Repetitive Mild Traumatic Brain Injury 94%
- The CB1 Negative Allosteric Modulator PSNCBAM-1 Reduces Ethanol Self-Administration via a Nonspecific Hypophagic Effect 94%
Similar papers in this journal
- Nicotine and Opioid Polysubstance Abuse: Enhancement of opioid self-administration by systemic nicotine and modulation of opioid-associated memories by insular nicotine 94%
- Nandrolone alters the behavioral response to cocaine as well as striatal and cortical dopamine receptors of prepubertal male rats. 94%
- Experimenter familiarization is a crucial prerequisite for assessing behavioral outcomes and reduces stress in mice not only under chronic pain conditions 94%
Similar papers in this journal
- Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice 96%
- Sex- and age- dependent effect of pre-gestational chronic stress and mirtazapine treatment on neurobehavioral development of offspring 94%
- Tesofensine, a novel antiobesity drug, silences GABAergic hypothalamic neurons 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.