Back

Sleep and circadian biomarkers of postoperative delirium: protocol for a prospective, observational cohort study

Sugg, E.; Gleeson, E.; Baker, S. N.; Li, P.; Gao, C.; Mueller, A. L.; Deng, H.; Shen, S.; Franco Garcia, E.; Saxena, R.; Musiek, E.; Johnson-Akeju, O.; Xie, Z.; Hu, K.; Gao, L.

2023-09-23 anesthesia
10.1101/2023.09.21.23295920 medRxiv
Show abstract

Surgical patients over 70 experience postoperative delirium (POD) complications in up to 50% of procedures. Sleep/circadian disruption has emerged as a potential risk factor for POD in epidemiological studies. However, the relationship remains unclear in a clinical setting. This protocol presents a single-site, prospective, noninvasive observational study designed to examine the relationship between sleep/circadian regulation and POD and how this association is influenced by AD pathology and genetic risk for AD. This novel approach for understanding modifiable risk factors of POD and cognitive decline after surgery could assist with establishing treatments and preventative measures for POD in the future.

Matching journals

The top 2 journals account for 50% of the predicted probability mass.

1
Brain, Behavior, and Immunity
○ 105 papers in training set
Top 0.1%
41.5%
2
Annals of Neurology
○ 57 papers in training set
Top 0.1%
19.6%
50% of probability mass above
3
PLOS ONE
● 4510 papers in training set
Top 23%
7.6%
4
Sleep
◐ 26 papers in training set
Top 0.3%
2.7%
5
British Journal of Anaesthesia
○ 14 papers in training set
Top 0.3%
2.5%
6
Scientific Reports
○ 3102 papers in training set
Top 48%
2.2%
7
Translational Psychiatry
○ 219 papers in training set
Top 3%
1.8%
8
SLEEP
◐ 28 papers in training set
Top 0.2%
1.8%
9
Frontiers in Medicine
○ 113 papers in training set
Top 4%
1.4%
10
Frontiers in Aging Neuroscience
○ 67 papers in training set
Top 3%
1.0%
11
Communications Biology
○ 886 papers in training set
Top 17%
0.9%
12
Neurology
○ 44 papers in training set
Top 1%
0.8%
13
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences
◐ 22 papers in training set
Top 0.3%
0.8%
14
Food & Function
● 12 papers in training set
Top 0.5%
0.8%
15
PLOS Biology
● 408 papers in training set
Top 18%
0.8%
16
Brain
◐ 154 papers in training set
Top 4%
0.8%
17
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
○ 38 papers in training set
Top 1.0%
0.8%
18
npj Parkinson's Disease
○ 89 papers in training set
Top 1.0%
0.8%
19
eneuro
● 389 papers in training set
Top 9%
0.8%
20
BMC Public Health
○ 147 papers in training set
Top 5%
0.8%
21
iScience
○ 1063 papers in training set
Top 31%
0.8%
22
Journal of Alzheimer’s Disease
○ 39 papers in training set
Top 1%
0.5%
23
Cells
○ 232 papers in training set
Top 8%
0.5%