Sleep and circadian biomarkers of postoperative delirium: protocol for a prospective, observational cohort study
Sugg, E.; Gleeson, E.; Baker, S. N.; Li, P.; Gao, C.; Mueller, A. L.; Deng, H.; Shen, S.; Franco Garcia, E.; Saxena, R.; Musiek, E.; Johnson-Akeju, O.; Xie, Z.; Hu, K.; Gao, L.
Show abstract
Surgical patients over 70 experience postoperative delirium (POD) complications in up to 50% of procedures. Sleep/circadian disruption has emerged as a potential risk factor for POD in epidemiological studies. However, the relationship remains unclear in a clinical setting. This protocol presents a single-site, prospective, noninvasive observational study designed to examine the relationship between sleep/circadian regulation and POD and how this association is influenced by AD pathology and genetic risk for AD. This novel approach for understanding modifiable risk factors of POD and cognitive decline after surgery could assist with establishing treatments and preventative measures for POD in the future.
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