Geranylgeranyl pyrophosphate (GGPP) is associated with hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4
Li, C.; Zhao, Y.; Jiang, S.; Nie, H.-Y.; Zhao, M.-F.; Sun, P.; Zhang, J.-Z.; Wang, X.-C.; Tang, Y.-P.; Yuan, X.-W.; Sun, X.-T.; Shan, X.-D.; He, J.; Liu, J.-H.; Bi, Y.; Fang, L.; Han, X.
Show abstract
Metabolically Abnormal Obesity (MAO) is characterized by hepatic steatosis and type 2 diabetes (T2D), in contrast to Metabolically Healthy Obesity (MHO). In this study, we investigated the role of hepatic geranylgeranyl pyrophosphate (GGPP), a metabolite of the mevalonate (MVA) pathway, in regulating the differences in lipid metabolism between MAO and MHO. Our findings revealed that GGPP levels were significantly elevated in individuals with MAO, and deficiency of GGPP in the liver ameliorated the defects associated with MAO. Furthermore, we discovered that the prenylation of the lipid droplet-associated protein Perilipin 4 by GGPP enhances the formation of large lipid droplets, thereby exacerbating hepatic lipid accumulation and insulin resistance. Notably, the inhibitor DGBP, targeting the GGPP synthase Ggpps, effectively attenuated the traits of MAO, offering novel insights into the treatment of this condition.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA 97%
- Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges 97%
- Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice 96%
Similar papers in this journal
- Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via beta-Klotho and Perilipin 2 96%
- Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice 96%
- Differential cell type-specific function of the aryl hydrocarbon receptor and its repressor in diet-induced obesity and fibrosis 95%
Similar papers in this journal
- Tumor cell-specific loss of GPX4 reprograms triacylglycerol metabolism to escape ferroptosis and impair antitumor immunity in NSCLC 93%
- Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine 91%
- Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver 91%
Similar papers in this journal
- Estrogen Receptor 1 Signaling in Hepatic Stellate Cells Designates Resistance to Liver Fibrosis 94%
- Metabolic control of histone acetylation for precise and timely regulation of minor ZGA in early mammalian embryos 92%
- Human DDIT4L intron retention contributes to cognitive impairment and amyloid plaque formation. 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.