Brain organoid-on-a-chip to create multiple domains in forebrain organoids
Tsai, Y.-C.; Ozaki, H.; Morikawa, A.; Shiraiwa, K.; Pin, A. P.; Salem, A. G.; Phommahasay, K. A.; Sugita, B. K.; Vu, C. H.; Mamoun Hammad, S.; Kamei, K.-i.; Watanabe, M.
Show abstract
Brain organoids are three-dimensionally reconstructed brain tissue derived from pluripotent stem cells in vitro. 3D tissue cultures have opened new avenues for exploring development and disease modeling. However, some physiological conditions, including signaling gradients in 3D cultures, have not yet been easily achieved. Here, we introduce Brain Organoid-on-a-Chip platforms that generate signaling gradients that in turn enable the induction of topographic forebrain organoids. This creates a more continuous spectrum of brain regions and provides a more complete mimic of the human brain for evaluating neurodevelopment and disease in unprecedented detail.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy 95%
- Establishment of physiologically relevant oxygen gradients in microfluidic organ chips 94%
- Microfluidics-enabled 96-well perfusion system for high-throughput tissue engineering and long-term all-optical electrophysiology 94%
Similar papers in this journal
- An automated microfluidic platform integrating functional vascularized organoids-on-chip 96%
- Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion, and drug screening 94%
- 3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels 94%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.