Sparse clustered inhibition projects sequential activity onto unique neural subspaces
Lehr, A. B.; Kumar, A.; Tetzlaff, C.
Show abstract
Neural activity in the brain traces sequential trajectories on low dimensional subspaces. For flexible behavior, these neural subspaces must be manipulated and reoriented within short timescales of tens of milliseconds. Using mathematical analysis and simulation of a recurrently connected neural circuit for sequence generation, we report that incorporating a subtype of interneurons that provides spatially heterogeneous inhibition enables the projection of sequential activity onto task- or context-specific neural subspaces. Depending on the sparsity of inhibitory projections, neural subspaces could be arbitrarily rotated, without altering the key aspects of sequence generation. Thus, we propose a circuit motif by which inhibitory interneurons can enable flexible switching between neural subspaces on a fast timescale of milliseconds, controlled by top down signals.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Two roles for choice selective inhibition in decision-making circuits 98%
- Influence of On-Off dynamics and selective attention on the spatial pattern of correlated variability in neocortex 97%
- Theory of spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity 97%
Similar papers in this journal
- Theory of Neuronal Perturbome: Linking Connectivity to Coding via Perturbations 98%
- Random noise promotes slow heterogeneous synaptic dynamics important for robust working memory computation 97%
- Modeling and dissociation of intrinsic and input-driven neural population dynamics underlying behavior 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.