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Septoria tritici blotch resistance gene Stb15 encodes a lectin receptor-like kinase

Hafeez, A. N.; Chartrain, L.; Cong, F.; Cambon, F.; Clarke, M.; Griffiths, S.; Hayta, S.; Jiang, M.; Keller, B.; Kirby, R.; Kolodziej, M. C.; Powell, O. R.; Smedley, M.; Steuernagel, B.; Xian, W.; Wingen, L. U.; Cheng, S.; Saintenac, C.; Wulff, B. B. H.; Brown, J. K. M.

2023-09-12 genetics
10.1101/2023.09.11.557217 bioRxiv
Show abstract

Septoria tritici blotch (STB), caused by the Dothideomycete fungus Zymoseptoria tritici, is of one of the most damaging diseases of bread wheat (Triticum aestivum)1 and the target of costly fungicide applications2. In line with the fungus apoplastic lifestyle, STB resistance genes isolated to date encode receptor-like kinases (RLKs) including a wall-associated kinase (Stb6) and a cysteine-rich kinase (Stb16q)3,4. Here, we used genome-wide association studies (GWAS) on a panel of 300 whole-genome shotgun-sequenced diverse wheat landraces (WatSeq consortium) to identify a 99 kb region containing six candidates for the Stb15 resistance gene. Mutagenesis and transgenesis confirmed a gene encoding an intronless G-type lectin RLK (LecRK) as Stb15. The characterisation of Stb15 exemplifies the unexpected diversity of RLKs conferring Z. tritici resistance in wheat.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.