Disease trajectories in hospitalized COVID-19 patients are predicted by clinical and peripheral blood signatures representing distinct lung pathologies.
Silva Filho, J. L.; Herder, V.; Gibbins, M. P.; dos Reis, M. F. F.; Melo, G. C.; Haley, M.; Judice, C. C.; Val, F. F. A.; Borba, M.; Tavella, T. A.; Sampaio, V. S.; Attipa, C.; McMonagle, F.; de Lacerda, M. V. G.; Costa, F. T. M.; Couper, K. N.; Monteiro, W. M.; Ferreira, L. C. d. L.; Moxon, C. A.; Palmarini, M.; Marti, M.
Show abstract
Linking clinical biomarkers and lung pathology still is necessary to understand COVID-19 pathogenesis and the basis of progression to lethal outcomes. Resolving these knowledge gaps enables optimal treatment approaches of severe COVID-19. We present an integrated analysis of longitudinal clinical parameters, blood biomarkers and lung pathology in COVID-19 patients from the Brazilian Amazon. We identified core signatures differentiating severe recovered patients and fatal cases with distinct disease trajectories. Progression to early death was characterized by rapid and intense endothelial and myeloid activation, presence of thrombi, mostly driven by SARS-CoV-2+ macrophages. Progression to late death was associated with systemic cytotoxicity, interferon and Th17 signatures and fibrosis, apoptosis, and abundant SARS-CoV-2 + epithelial cells in the lung. Progression to recovery was associated with pro-lymphogenic and Th2-mediated responses. Integration of ante-mortem clinical and blood biomarkers with post-mortem lung-specific signatures defined predictors of disease progression, identifying potential targets for more precise and effective treatments.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesis 96%
- Functional proteomic profiling links deficient DNA clearance to mortality in patients with severe COVID-19 pneumonia 96%
- Early immune pathology and persistent dysregulation characterise severe COVID-19 96%
Similar papers in this journal
Similar papers in this journal
- Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection 96%
- Inflammation in the tumor-adjacent lung as a predictor of clinical outcome in lung adenocarcinoma 95%
- Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates 95%
Similar papers in this journal
Similar papers in this journal
- Deep immune profiling reveals early-stage and highly coordinated immune responses in mild COVID-19 patients 95%
- Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patients 95%
- A distinct innate immune signature marks progression from mild to severe COVID-19 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.