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Investigating a causal role for neutrophil count on P. falciparum severe malaria: a Mendelian Randomization study
2023-09-07
epidemiology
Title + abstract only
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BackgroundMalaria caused by P. falciparum imposes a tremendous public health burden on people living in sub-Saharan Africa. Severe malaria is associated with high morbidity and mortality and results from complications such as cerebral malaria, severe anaemia or respiratory distress. Individuals living in malaria endemic regions often have a reduced circulating neutrophil count due to a heritable phenomenon called benign ethnic neutropenia (BEN). Neutrophils defend against bacterial infections b...
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