Low albumin status accompanies multi-layered immunosuppressive phenotypes in metastatic breast cancer patients
Nakamura, Y.; Yoda, M.; Izumi, Y.; Kashima, Y.; Takahashi, M.; Nakatani, K.; Bamba, T.; He, C.; Konishi, R.; Saldajeno, D. P.; Vandenbon, A.; Suzuki, Y.; Toi, M.; Kawaguchi, K.; Kawaoka, S.
Show abstract
Low albumin status is prevalent in advanced cancer patients, but the pathophysiology associated with this anomaly remains largely unexplored. To address this, we aim to search correlations of albumin levels with the transcriptome against peripheral blood mononuclear cells and the plasma metabolome within the same patients having metastatic breast cancers. We confirm that metastatic breast cancer patients exhibit low albumin levels in varying degrees without prominent systemic inflammation. Our data demonstrate that low albumin levels correlate with transcriptome signatures indicative of "neutrophil activation and T-cell down-regulation," an immunosuppressive phenotype. We also find that immunoregulatory metabolites, such as arginine, are reduced in plasma in an albumin-correlated manner, further corroborating systemic immunosuppression. These results are verified using a mouse model of breast cancer. We conclude that low albumin status in metastatic breast cancer patients accompanies immunosuppressive phenotypes, which is likely unfavorable for anti-cancer immunotherapy and thus can be a cause of unsuccessful treatment outcomes.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Integration of scHi-C and scRNA-seq data defines distinct 3D-regulated and biological-context dependent cell subpopulations 97%
- Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in thetumor microenvironment 96%
- An improved epigenetic counter to track mitotic age in normal and precancerous tissues 96%
Similar papers in this journal
- Elucidating immune-related gene transcriptional programs via factorization of large-scale RNA-profiles 97%
- Multimodal analysis unveils tumor microenvironment heterogeneity linked to immune activity and evasion 97%
- Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer 97%
Similar papers in this journal
Similar papers in this journal
- Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages 96%
- Cancer-associated fibroblast compositions change with breast cancer progression linking S100A4 and PDPN ratios with clinical outcome 96%
- Multi-modal digital pathology for colorectal cancer diagnosis by high-plex immunofluorescence imaging and traditional histology of the same tissue section 96%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.