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Sensitivity of BA.2.86 to prevailing neutralising antibody responses

Sheward, D. J.; Yang, Y.; Westerberg, M.; Öling, S.; Muschiol, S.; Sato, K.; Peacock, T. P.; Karlsson Hedestam, G. B.; Albert, J.; Murrell, B.

2023-09-04 immunology
10.1101/2023.09.02.556033 bioRxiv
Show abstract

A new SARS-CoV-2 variant, designated BA.2.86, has recently emerged with over 30 spike mutations relative to its parental BA.2, raising questions about its degree of resistance to neutralising antibodies. Using a spike-pseudotyped virus model we characterise neutralisation of BA.2.86 by clinically relevant monoclonal antibodies and by two cohorts of serum sampled from Stockholm, including both a recent cohort, and one sampled prior to the arrival of XBB in Sweden.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.