Loss of RND3/RHOE controls entosis through LAMP1 expression in hepatocellular carcinoma
Basbous, S.; Dif, L.; Dantzer, C.; Di Tommaso, S.; Dupuy, J.-W.; Bioulac-Sage, P.; Raymond, A.-A.; Desdouets, C.; Saltel, F.; Moreau, V.
Show abstract
Entosis is a process that leads to the formation of cell-in-cell structures commonly found in cancers. Here, we identified entosis in hepatocellular carcinoma and the loss of Rnd3 as an efficient inducer of this mechanism. We characterized the different stages and the molecular regulators of entosis induced after Rnd3 silencing. We demonstrated that this process depends on RhoA/ROCK pathway, but not on E-cadherin. The proteomic profiling of entotic cells allowed us to identify LAMP1 as a protein upregulated by Rnd3 silencing and implicated not only in the degradation final stage of entosis, but also in the full mechanism. Moreover, we found a positive correlation between the presence of entotic cells and the metastatic potential of tumors in human patient samples. Altogether, these data suggest the involvement of entosis in liver tumor progression and highlight a new perspective for entosis analysis in medicine research as a novel therapeutic target.
Matching journals
The top 9 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The oncogenic E3 ligase TRIP12 suppresses epithelial-mesenchymal transition (EMT) and metastasis-related processes through ZEB1/2 94%
- NSD1 supports cell growth and regulates autophagy in HPV-negative head and neck squamous cell carcinoma. 93%
- Tumors cells with mismatch repair deficiency induce hyperactivation of Pyroptosis resistant to cell membrane damage but are more sensitive to Co-treatment of IFN-γ and TNF-α to PANoptosis 92%
Similar papers in this journal
- Differential modulation of miR-122 transcription by TGFbeta1/BMP6: implications for nonresolving inflammation and hepatocarcinogenesis 93%
- Down-regulation of AKT proteins slows the growth of mutant-KRAS pancreatic tumors 92%
- Mutant KRAS-associated proteome is mainly controlled by exogenous factors 92%
Similar papers in this journal
- A Positive Regulatory Feedback Loop Between 1 EKLF/ KLF1 and TAL1/SCL2 Sustaining the Erythropoiesis 93%
- Kinase Suppressor of RAS 1 (KSR1) maintains the transformed phenotype of BRAFV600E mutant human melanoma cells 93%
- The large GTPase Guanylate-Binding Protein-1 (GBP-1) promotes mitochondrial fission in glioblastoma. 92%