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Validation study for noninvasive single-cell-based prenatal genetic testing

2023-08-31 genetic and genomic medicine Title + abstract only
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ObjectiveTo clinically validate a cell-based noninvasive prenatal genetic test using sequence-based copy number analysis of single trophoblasts from maternal blood. MethodsBlood was obtained from 401 individuals (8-22 weeks) and shipped overnight. Red blood cells were lysed, and nucleated cells stained for cytokeratin (CK) and CD45 using fluorescent antibodies and enriched for positive CK staining. Automated microscopic scanning was used to identify and pick single CK+/CD45- trophoblasts which ...

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