Environmental circadian disruption re-programs liver circadian gene expression
Duong, H. A.; Baba, K.; DeBruyne, J.; Davidson, A. J.; Ehlen, J. C.; Powell, M. D.; Tosini, G.
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Circadian gene expression is fundamental to the establishment and functions of the circadian clock, a cell-autonomous and evolutionary-conserved timing system. Yet, how it is affected by environmental-circadian disruption (ECD) such as shiftwork and jetlag, which impact millions of people worldwide, are ill-defined. Here, we provided the first comprehensive description of liver circadian gene expression under normal and after ECD conditions. We found that post-transcription and post-translation processes are dominant contributors to whole-cell or nuclear circadian proteome, respectively. Furthermore, rhythmicity of 64% transcriptome, 98% whole-cell proteome and 95% nuclear proteome is re-written by ECD. The re-writing, which is associated with changes of circadian cis-regulatory elements, RNA-processing and protein trafficking, diminishes circadian regulation of fat and carbohydrate metabolism and persists after one week of ECD-recovery. One-Sentence SummaryEnvironmental-circadian disruption re-writes the circadian gene expression process which persists after one week of recovery.
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