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No observed effect concentration (NOEC) and minimal effective dose (MED): estimation of non-experimental doses

Hothorn, L. A.

2023-08-24 pharmacology and toxicology
10.1101/2023.08.23.554562 bioRxiv
Show abstract

In in-vitro or in-vivo bioassays, the no observed effect concentration (NOEC) is often determined. This simple procedure has several disadvantages, including the limitation of being able to estimate only experimental doses. Linear interpolation between adjacent doses overcomes this drawback while maintaining the level of a familywise error rate (FWER) using multiple contrast tests.

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