Innate immune control of influenza virus interspecies adaptation
Denz, P. J.; Speaks, S.; Kenney, A. D.; Eddy, A. C.; Papa, J. L.; Roettger, J.; Scace, S. C.; Hemann, E. A.; Forero, A.; Webby, R. J.; Bowman, A. S.; Yount, J. S.
Show abstract
Influenza virus pandemics are caused by viruses from animal reservoirs that adapt to efficiently infect and replicate in human hosts. Here, we investigated whether Interferon-Induced Transmembrane Protein 3 (IFITM3), a host antiviral factor with known human deficiencies, plays a role in interspecies virus infection and adaptation. We found that IFITM3-deficient mice and human cells could be infected with low doses of avian influenza viruses that failed to infect WT counterparts, identifying a new role for IFITM3 in controlling the minimum infectious viral dose threshold. Remarkably, influenza viruses passaged through Ifitm3-/- mice exhibited enhanced host adaptation, a result that was distinct from passaging in mice deficient for interferon signaling, which caused virus attenuation. Our data demonstrate that IFITM3 deficiency uniquely facilitates zoonotic influenza virus infections and subsequent adaptation, implicating IFITM3 deficiencies in the human population as a vulnerability for emergence of new pandemic viruses.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- CRISPR with Transcriptional Readout reveals influenza transcriptionis modulated by NELF and can precipitate an interferon response 97%
- Orthogonal genome-wide screenings in bat cells identify MTHFD1 as a target of broad antiviral therapy 96%
- Whole Virion Proteomics of HCMV Reveals that gpUL141 is a Virion Component that Regulates Envelope Glycoprotein Composition to Protect Against Humoral Immunity 96%
Similar papers in this journal
- A protective and broadly binding antibody class engages the influenza virus hemagglutinin head at its stem interface 95%
- DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication 95%
- Interferon-Inducible Guanylate-Binding Protein 5 Inhibits Replication of Multiple Viruses by Binding to the Oligosaccharyltransferase Complex and Inhibiting Glycoprotein Maturation 95%
Similar papers in this journal
- Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant 97%
- Systems immunology of transcriptional responses to viral infection identifies conserved antiviral pathways across macaques and humans 96%
- Antigenic and virological properties of an H3N2 variant that will likely dominate the 2021-2022 Northern Hemisphere influenza season 96%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.