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Non-linear mendelian randomization: evaluation of biases using negative controls with a focus on BMI and Vitamin D

2023-08-22 epidemiology Title + abstract only
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Mendelian randomisation (MR) is an established technique in epidemiological investigation, using the principle of random allocation of genetic variants at conception to estimate the causal linear effect of an exposure on an outcome. Extensions to this technique include non-linear approaches that allow for differential effects of the exposure on the outcome depending on the level of the exposure. A widely used non-linear method is the residual approach, which estimates the causal effect within di...

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