Striatal dopamine release reflects a multi-factorial prediction error
Costa, K. M.; Raheja, N.; Mirani, J.; Sercander, C.; Schoenbaum, G.
Show abstract
Dopamine is classically thought to drive learning based on errors in the prediction of rewards and punishments 1. However, animals also learn to predict cues with no intrinsic value 2, and it is unclear if such latent learning also relies on dopaminergic prediction errors. Here, we tested this by recording dopamine release in the nucleus accumbens and dorsomedial striatum while rats executed a sensory preconditioning task that incorporates both types of learning 3. We found that dopamine release in both regions correlated with errors in predicting value-neutral cues during latent learning and with errors in predicting reward during reward-based conditioning. Moreover, dopamine in the nucleus accumbens reflected inferred value in the probe test, supported by orbitofrontal cortex activity. Our findings suggest that dopamine signals a domain- general, multi-factorial prediction error, capable of supporting model-based learning.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Chemogenetic activation of mesoaccumbal {Gamma}-Aminobutyric Acid projections selectively tunes responses to predictive cues when reward value is abruptly decreased 96%
- Cumulative effects of social stress on reward-guided actions and prefrontal cortical activity 96%
- Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin 96%
Similar papers in this journal
- Dopamine supports reward prediction to shape reward-pursuit strategy 95%
- The medial orbitofrontal cortex - basolateral amygdala circuit regulates the influence of reward cues on adaptive behavior and choice 95%
- Anticipation of appetitive operant action induces sustained dopamine release in the nucleus accumbens 95%
Similar papers in this journal
- Amphetamine disrupts haemodynamic correlates of prediction errors in nucleus accumbens and orbitofrontal cortex 96%
- Dorsomedial striatal neuroinflammation causes excessive goal-directed action control by disrupting astrocyte function 96%
- The bed nucleus of the stria terminalis mediates the expression of proactive defensive behavior 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.