Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
Moreno, A.; Manning, K.; Azeem, M. I.; Nooka, A. K.; Ellis, M.; Manalo, R. J.; Switchenko, J. M.; Wali, B.; Kaufman, J. L.; Hofmeister, C. C.; Joseph, N. S.; Lonial, S.; Dhodapkar, K. M.; Dhodapkar, M. V.; Suthar, M. S.
Show abstract
We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.
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