Unraveling the Dual-Mode Impact on Tension Gauge Tethers' Mechanical Stability
Liu, J.; Yan, J.
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Tension Gauge Tethers (TGTs), short DNA segments serving as extracellular tension sensors, are instrumental in assessing tension dynamics in mechanotransduction. These TGTs feature an initial shear-stretch region and an unzip-stretch region. Despite their utility, no theoretical model has been available to estimate their tension-dependent lifetimes ({tau} (f)), restricting insights from cellular mechanotransduction experiments. Weve now formulated a concise expression for{tau} (f) of TGTs, accommodating contributions from both stretch regions. Our model uncovers a tension-dependent energy barrier shift occurring when tension surpasses a switching force approximately 13 pN for the recently developed TGTs, greatly influencing{tau} (f) profiles. Experimental data from several TGTs validated our model. The calibrated expression can predict{tau} (f) of TGTs at 37 degrees Celsius based on their sequences with minor fold-changes, supporting future applications of TGTs.
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