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Neurons in the human entorhinal cortex map abstract emotion space

Qasim, S. E.; Reinacher, P. C.; Brandt, A.; Schulze-Bonhage, A.; Kunz, L.

2023-08-12 neuroscience
10.1101/2023.08.10.552884 bioRxiv
Show abstract

When animals move through space, neurons in their entorhinal cortex activate periodically at multiple locations to form a map of the spatial environment. These grid cells may also map non-physical, conceptual spaces to support various other complex behaviors. Here, using intracranial recordings in neurosurgical patients performing an emotional memory task, we find that neurons in the human medial temporal lobe activate in a grid-like pattern across a two-dimensional feature space characterized by emotional valence and arousal. These neurons were different from cells tuned solely to valence or arousal, were preferentially located in the entorhinal cortex, and exhibited theta-phase locking. Our observation of grid-like neuronal activity during emotional processing in humans supports the idea that the neural structure of cognitive maps generalizes beyond spatial navigation.

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