Three Accessory Gene Clusters Drive Host-Adaptation in Group B Streptococcus
Crestani, C.; Forde, T. L.; Bell, J.; Lycett, S. J.; Oliveira, L. M.; Pinto, T. C.; Cobo-Angel, C. G.; Ceballos-Marquez, A.; Phuoc, N. N.; Sirimanapong, W.; Chen, S. L.; Jamrozy, D.; Bentley, S. D.; Fontaine, M.; Zadoks, R. N.
Show abstract
Streptococcus agalactiae (Group B Streptococcus, GBS) is a major pathogen of humans and animals, posing a threat to human health as well as food security. Here, we investigate the role of genomic mechanisms, including homologous recombination and horizontal gene transfer, in shaping the population structure of GBS and its adaptation to three major host groups (humans, cattle, fishes). We demonstrate that the GBS population comprises host-specialist, host-adapted lineages as well as host generalists, and that these categories differ in their level or recombination. Although the accessory genome at large varies by lineage rather than host, genome wide association studies show that host association is driven by three accessory genome clusters, regardless of lineage or breadth of the host spectrum. These genomic clusters (scpB in human GBS, lactose operon in bovine GBS, Locus 3 in fish GBS) are known (scpB, Lac.2) or shown here (Locus 3) to be functionally relevant and are shared with other streptococcal species occupying the same host niche. These findings demonstrate the importance of considering the role of non-human host species in the evolution of GBS, including high risk clones that may lead to interspecies transmission and affect efficacy of future GBS vaccines.
Matching journals
The top 8 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Genomics of Irish swine-derived Streptococcus suis: Population structure, prophages, and anti-viral defence mechanisms 97%
- Two cases of type-a Haemophilus influenzae meningitis within the same week in the same hospital are phylogenetically unrelated but recently exchanged capsule genes 95%
- Rapid molecular evolution of Spiroplasma symbionts of Drosophila 95%
Similar papers in this journal
- Travel-driven emergence and spread of SARS-CoV-2 lineage B.1.620 with multiple VOC-like mutations and deletions in Europe 95%
- Population analysis of Legionella pneumophila reveals the basis of resistance to complement-mediated killing 95%
- A unique symbiosome in an anaerobic single-celled eukaryote 93%
Similar papers in this journal
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.