Vitamin D deficiency induces erectile dysfunction: role of superoxide
Olivencia, M. A.; Climent, B.; Barreira, B.; Morales-Cano, D.; Sanchez, A.; Fernandez, A.; Garcia-Gomez, B.; Romero-Otero, J.; Rodriguez, C.; Moreno, L.; Prieto, D.; Larriba, M. J.; Cogolludo, A.; Angulo, J.; Perez-Vizcaino, F.
Show abstract
Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED) but its causal relationship and the mechanism involved are unclear. Here we demonstrate that isolated corpora cavernosa (CC) from human donors with low vitamin D levels show reduced NO-dependent erectile function. This ED is also reproduced in vitamin D deficient rats and vitamin D receptor knockout mice in vivo and ex vivo and is associated with penile fibrosis. Vitamin D deficiency also blunts the response of CC to the phosphodiesterase 5 inhibitor sildenafil. CC from deficient rats show increased superoxide and their impaired erectile function is restored by superoxide scavengers. These results suggest that vitamin D deficiency induces ED via increased superoxide production.
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