Comprehensive identification of potentially functional genes for transposon mobility in the C. elegans genome
Arata, Y.; Jurica, P.; Parrish, N. F.; Sako, Y.
Show abstract
Transposons are mobile DNA elements that encode genes for their own mobility. Whereas transposon copies accumulate on the genome during evolution, many lose their mobile activity due to mutations. Here, we focus on transposon-encoded genes that are directly involved in the replication, excision, and integration of transposon DNA, which we refer to as "transposon-mobility genes", in the Caenorhabditis elegans genome. Among the 62,773 copies of retro- and DNA transposons in the latest assembly of the C. elegans genome (VC2010), we found that the complete open reading frame structure was conserved in 290 transposon-mobility genes. Critical amino acids at the catalytic core were conserved in only 145 of these 290 genes. Thus, in contrast to the huge number of transposon copies in the genome, only a limited number of transposons are autonomously mobile. We conclude that the comprehensive identification of potentially functional transposon-mobility genes in all transposon orders of a single species can provide a basis of molecular analysis for revealing the developmental, aging, and evolutionary roles of transposons.
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation 94%
- Differential efficacies of Cas nucleases on microsatellites involved in human disorders and associated off-target mutations 92%
- Laboratory evolution of the bacterial genome structure through insertion sequence activation 92%
Similar papers in this journal
- Rapid gene evolution in an ancient post-transcriptional and translationalregulatory system compensates for meiotic X chromosomal inactivation 94%
- Tirant stealthily invaded natural Drosophila melanogaster populations during the last century 93%
- Paleozoic Protein Fossils Illuminate the Evolution of Vertebrate Genomes and Transposable Elements 93%
Similar papers in this journal
- In and outs of Chuviridae endogenous viral elements: origin of a retrovirus and signature of ancient and ongoing arms race in mosquito genomes 92%
- RESIC: A tool for comprehensive adenosine to inosine RNA Editing Site Identification and Classification 92%
- tRNA fragments (tRFs) populations analysis in mutants affecting tRNAs processing and tRNA methylation 91%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.