Tissue-wide scRNA-seq analysis reveals enrichment of imprinted genes in stem and endocrine cell-types in mice
Higgs, M. J.; Hill, M. J.; John, R. M.; Isles, A. R.
Show abstract
Enriched expression of imprinted genes may provide evidence of convergent function. Here we interrogated five single-cell RNA sequencing datasets to identify imprinted gene over-representation in the embryonic and adult mouse focusing on tissues including the bladder, pancreas, mammary gland and muscle. We identify a consistent enrichment of imprinted genes in stromal cell and mesenchymal stem cell populations across these tissues, suggesting a role in tissue maintenance. Furthermore, we identify a distinct enrichment in the endocrine islets of the mouse pancreas, over and above the stromal/stem cells from this tissue. Taken together with our previous work examining imprinted gene expression in cell subpopulations of the adult mouse brain and pituitary gland, these data suggest that genomic imprinting influences physiology largely via separate systems of cell populations either involved in hormonal signalling or in stemness and cell-fate co-ordination.
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Evolutionary Perspective And Expression Analysis Of Intronless Genes Highlight The Conservation On Their Regulatory Role 93%
- Reference transcriptomes of porcine peripheral immune cells created through bulk and single-cell RNA sequencing 92%
- A tissue specific atlas of gene promoter DNA methylation variability and the clinical value of its assessment 91%
Similar papers in this journal
- Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes 92%
- Human Gene Expression Variability and its Dependence on Methylation and Aging 91%
- Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancers 91%
Similar papers in this journal
- Assessment of the Histone Mark-based Epigenomic Landscape in Human Myometrium at Term Pregnancy 93%
- Dynamics of transcriptional programs and chromatin accessibility in mouse spermatogonial cells from early postnatal to adult life 93%
- A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells 92%
Similar papers in this journal
- Single-cell transcriptome analysis of embryonic and adult endothelial cells allows to rank the hemogenic potential of post-natal endothelium 93%
- WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations 92%
- scSPLAT, a scalable plate-based protocol for single cell WGBS library preparation 92%
Similar papers in this journal
- Dynamic Features of Chromosomal Instability during Culture of Induced Pluripotent Stem Cells 91%
- Transcriptional differences for COVID-19 Disease Map genes between males and females indicate a different basal immunophenotype relevant to the disease 91%
- Retinoic acid-regulated epigenetic marks identify Alx1 as a direct target gene required for optic cup formation 90%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.