FAM210A mediates an inter-organelle crosstalk essential for protein synthesis and muscle growth in mouse
Chen, J.; Yue, F.; Kim, K. H.; Zhu, P.; Qiu, J.; Tao, W. A.; Kuang, S.
Show abstract
Mitochondria are not only essential for energy production in eukaryocytes but also a key regulator of intracellular signaling. Here, we report an unappreciated role of mitochondria in regulating cytosolic protein translation in skeletal muscle cells (myofibers). We show that the expression of mitochondrial protein FAM210A (Family With Sequence Similarity 210 Member A) is positively associated with muscle mass in mice and humans. Muscle-specific Myl1Cre-driven Fam210a knockout (Fam210aMKO) in mice reduces mitochondrial density and function, leading to progressive muscle atrophy and premature death. Metabolomic and biochemical analyses reveal that Fam210aMKO reverses the oxidative TCA cycle towards the reductive direction, resulting in acetyl-CoA accumulation and hyperacetylation of cytosolic proteins. Specifically, hyperacetylation of several ribosomal proteins leads to disassembly of ribosomes and translational defects. Transplantation of Fam210aMKO mitochondria into wildtype myoblasts is sufficient to elevate protein acetylation in recipient cells. These findings reveal a novel crosstalk between the mitochondrion and ribosome mediated by FAM210A.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Lipid hydroperoxides promote sarcopenia through carbonyl stress 96%
- Integrative study of skeletal muscle mitochondrial dysfunction in a murine pancreatic cancer-induced cachexia model 96%
- LSD1 acts as an epigenetic barrier against glucocorticoid-induced atrophy and exercise-induced hypertrophy in skeletal muscle 96%
Similar papers in this journal
- The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms 97%
- Human skeletal muscle fiber heterogeneity beyond myosin heavy chains 96%
- Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle 96%
Similar papers in this journal
- PGC-1α in the myofibers regulates the balance between myogenic and adipogenic progenitors affecting muscle regeneration 96%
- Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival 96%
- AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion 96%
Similar papers in this journal
- Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in Amyotrophic Lateral Sclerosis 96%
- Diurnal variation in skeletal muscle mitochondrial function dictates time of day-dependent differences in exercise capacity 96%
- Cancer causes dysfunctional insulin signaling and glucose transport in a muscle-type specific manner 94%
Similar papers in this journal
- Cell autonomous requirement of Neurofibromin (Nf1) for postnatal muscle hypertrophic growth and metabolic homeostasis 96%
- Tumor-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism 96%
- Decoding the transcriptome of denervated muscle at single-nucleus resolution 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.