Spontaneous enteric nervous system activity precedes maturation of gastrointestinal motility
Dershowitz, L. B.; Garcia, H. B.; Perley, A. S.; Coleman, T. P.; Kaltschmidt, J. A.
Show abstract
Spontaneous neuronal network activity is essential in development of central and peripheral circuits, yet whether this is a feature of enteric nervous system development has yet to be established. Using ex vivo gastrointestinal (GI) motility assays with unbiased computational analyses, we identify a previously unknown pattern of spontaneous neurogenic GI motility. We further show that this motility is driven by cholinergic signaling, which may inform GI pharmacology for preterm patients.
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