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Discovery of a multipotent cell type from the term human placenta

Vadakke-Madathil, S.; Wang, B.; Oniskey, M.; Dekio, F.; Brody, R.; Gelber, S.; Sperling, R.; Chaudhry, H. W.

2024-01-13 cell biology
10.1101/2023.08.02.551028 bioRxiv
Show abstract

We identify a population of multipotent CDX2 cells from term human placentas with clonal expansion, migratory capacity, and immune-privileged transcriptional profiles. Isolated from 180 healthy pregnancies, these cells differentiate into cardiomyocyte and vascular lineages in vitro and in vivo. Single-cell RNA sequencing uncovers distinct cardiogenic and vasculogenic subpopulations, along with immune-modulatory and chemotactic programs, providing a blueprint for precision-guided cardiovascular cell therapy. In a NOD/SCID myocardial infarction model, CDX2 cells restore cardiac function, and clonal propagation preserves their cardiovascular differentiation potential. These findings position placental CDX2 cells as an ethically accessible, regenerative platform for targeted treatment of cardiovascular disease.

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"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.