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Accuracy of retrospective birth location data - An analysis based on siblings

von Hinke, S.; Vitt, N.

2023-07-25 genomics
10.1101/2023.07.21.550064 bioRxiv
Show abstract

Many surveys ask participants to retrospectively record their location of birth. This paper examines the accuracy of such data in the UK Biobank using a sample of siblings. Comparison of reported birth locations for siblings with different age gaps allows us to estimate the probabilities of household moves and of misreported birth locations. We find an annual probability of 1.2% for household moves of one kilometre or more, suggesting that geographical mobility during childhood was low. Our results furthermore show a sizeable probability of misreporting, with 28% of birth coordinates, 16% of local districts and 6% of counties of birth being incorrectly reported. We show that such error can lead to substantial attenuation bias when investigating the impacts of location-based exposures, especially when there is little spatial correlation and limited time variation in the exposure variable. Sibling fixed effect models are shown to be particularly vulnerable to the attenuation bias.

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