Back

A Molecular Basis of Human Brain Connectivity

Ng, B.; Tasaki, S.; Greathouse, K.; Walker, C.; Zhang, A.; Covitz, S.; Cieslak, M.; Adamson, A.; Andrade, J.; Poovey, E.; Curtis, K.; Muhammad, H.; Seidlitz, J.; Satterthwaite, T.; Bennett, D.; Seyfried, N.; Vogel, J.; Gaiteri, C.; Herskowitz, J.

2023-07-24 neuroscience
10.1101/2023.07.20.549895 bioRxiv
Show abstract

Neuroimaging is commonly used to infer human brain connectivity, but those measurements are far-removed from the molecular underpinnings at synapses. To uncover the molecular basis of human brain connectivity, we analyzed a unique cohort of 98 individuals who provided neuroimaging and genetic data contemporaneous with dendritic spine morphometric, proteomic, and gene expression data from the superior frontal and inferior temporal gyri. Through cellular contextualization of the molecular data with dendritic spine morphology, we identified hundreds of proteins related to synapses, energy metabolism, and RNA processing that explain between-individual differences in functional connectivity and structural covariation. By integrating data at the genetic, molecular, subcellular, and tissue levels, we bridged the divergent fields of molecular biology and neuroimaging to identify a molecular basis of brain connectivity. One-Sentence SummaryDendritic spine morphometry and synaptic proteins unite the divergent fields of molecular biology and neuroimaging.

Matching journals

The top 5 journals account for 50% of the predicted probability mass.

1
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 1%
18.2%
Similar papers in this journal
2
Cerebral Cortex
◐ 396 papers in training set
Top 0.2%
12.5%
Similar papers in this journal
3
Nature Communications
○ 5641 papers in training set
Top 23%
7.2%
Similar papers in this journal
4
Communications Biology
○ 993 papers in training set
Top 0.7%
7.2%
Similar papers in this journal
5
Science Advances
● 1243 papers in training set
Top 3%
6.6%
50% of probability mass above
6
Cell Reports
○ 1498 papers in training set
Top 5%
6.6%
7
iScience
○ 1154 papers in training set
Top 1%
6.6%
Similar papers in this journal
8
Biological Psychiatry
○ 137 papers in training set
Top 0.5%
5.4%
9
eLife
● 5828 papers in training set
Top 25%
5.1%
10
Scientific Reports
○ 3612 papers in training set
Top 33%
3.2%
11
Network Neuroscience
● 126 papers in training set
Top 0.8%
2.1%
12
NeuroImage
○ 903 papers in training set
Top 4%
2.1%
13
Molecular Psychiatry
○ 282 papers in training set
Top 3%
1.7%
14
PNAS Nexus
◐ 159 papers in training set
Top 2%
1.1%
15
PLOS Computational Biology
● 1863 papers in training set
Top 17%
1.1%
16
Science
● 477 papers in training set
Top 8%
1.0%
17
PLOS Biology
● 486 papers in training set
Top 12%
0.8%
18
Neuron
○ 337 papers in training set
Top 5%
0.8%
19
Translational Psychiatry
○ 260 papers in training set
Top 4%
0.6%
20
PLOS ONE
● 5266 papers in training set
Top 63%
0.6%
21
Nature Neuroscience
○ 252 papers in training set
Top 5%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.