Enterocloster clostridioformis induces host intestinal epithelial responses that protect against Salmonella infection
Beresford-Jones, B. S.; Suyama, S.; Clare, S. A.; Soderholm, A. T.; Xia, W.; Sardar, P.; Harcourt, K.; Lawley, T. D.; Pedicord, V. A.
Show abstract
Promoting resistance to enteric pathogen infection is a core function of the gut microbiota. However, many of the host-commensal interactions that likely mediate this protection remain uncharacterised. By screening gnotobiotic mice monocolonised with a range of mouse-derived commensal bacteria we have identified Enterocloster clostridioformis as a protective species against Salmonella Typhimurium infection. Unlike the colonisation resistance induced by some commensal bacteria, E. clostridioformis selectively induces a previously uncharacterised microbe adaptation response at the level of the caecal intestinal epithelium and the underlying mucosal immune system to mediate host-dependent resistance to infection. Triggering this pathway may therefore constitute a novel strategy to enhance protective responses against enteric infections.
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