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A neuropsychological basis for temptation-resistant voluntary exercise

Tesmer, A. L.; Li, X.; Schmandt, C.; Polania, R.; Peleg-Raibstein, D.; Burdakov, D.

2023-07-19 neuroscience
10.1101/2023.07.19.549365 bioRxiv
Show abstract

Despite well-known health benefits of physical activity, many people under-exercise, and what drives prioritization of exercise over other alternatives is unclear. We implement a novel paradigm allowing to study how freely behaving mice rapidly display such prioritizing between time spent on wheel-running and other temptations such as palatable food. Causal manipulations and correlative analyses of underlying appetitive and consummatory psychobehavioral processes revealed this prioritizing to be instantiated by hypothalamic hypocretin/orexin neurons.

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