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Proteomic prediction of common and rare diseases
2023-07-23
epidemiology
Title + abstract only
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BackgroundFor many diseases there are delays in diagnosis due to a lack of objective biomarkers for disease onset. Whether measuring thousands of proteins offers predictive information across a wide range of diseases is unknown. MethodsIn 41,931 individuals from the UK Biobank Pharma Proteomics Project (UKB-PPP), we integrated [~]3000 plasma proteins with clinical information to derive sparse prediction models for the 10-year incidence of 218 common and rare diseases (81 - 6038 cases). We compa...
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