Left common trunkus pulmonary veins have genetic background and poorer rhythm outcome after paroxysmal atrial fibrillation catheter ablation

BackgroundThe genetic traits of pulmonary vein (PV) variants and rhythm outcomes after atrial fibrillation (AF) catheter ablation (AFCA) remain unclear. We explored the genetic and clinical characteristics and long-term rhythm outcomes of patients with AF and left common trunkus (LCT)-PVs or accessory PVs. MethodsWe included 2,829 patients with AF (74.0% men, age 59.1{+/-}10.7 years, 66.3% paroxysmal AF) and available genome-wide association study, cardiac computed tomography, and protocol-based regular rhythm follow-up results from the Yonsei AF ablation cohort database. We examined 1,223 single nucleotide polymorphisms in 12 genetic loci associated with AF and long-term rhythm outcomes after AFCA. ResultsWe found LCT-PVs in 91(3.2%) and accessory PVs in 189(6.7%) patients. Rs9871453 (SCN10A) and rs1979409 (NEO1) were significantly associated with LCT-PV occurrence, and polygenic risk score (PRS) differed significantly between patients with LCT-PVs (p=1.64e-05) and normal PVs, but not those with accessory PVs (p=0.939). Patients with LCT-PVs had a higher proportion of the female sex(p=0.046) and CHA2DS2VASc score (p=0.026). After follow-up for 39.7{+/-}4.7 months, patients with LCT-PVs exhibited significantly greater LCT anterior wall thicknesses (p<0.001) and higher recurrence rate than those with normal PVs, particularly patients with paroxysmal AF (log-rank, p=0.042). LCT-PVs were independently associated with AF recurrence after AFCA (hazard ratio[HR], 2.26 [1.01-4.42]; p=0.046). Patients with LCT-PVs and higher PRSs had a higher risk of recurrent AF (adjusted HR 1.78, 95% CI 1.10-2.88, p=0.019). ConclusionsPatients with LCT-PVs have a significant genetic background. Post-AFCA recurrence rate was significantly higher in patients with LCT-PVs and higher PRSs, particularly in those with paroxysmal AF. Clinical PerspectiveO_ST_ABSWhat Is New?C_ST_ABSThis study identifies specific genetic variants associated with the occurrence of LCT-PVs in AF patients undergoing catheter ablation. Higher AF recurrence rates were observed in LCT-PV patients, particularly those with paroxysmal AF. High-genetic risk LCT-PV patients exhibited increased AF recurrence and a thicker anterior wall of the left pulmonary vein compared to normal PV patients. What Are the Clinical Implications?The findings enhance our understanding of the genetic basis of AF and its anatomical manifestations, enabling personalized treatment approaches. Further research is needed to identify additional genetic variants associated with LCT-PV and to understand the recurrence of AF when using methods other than catheter ablation.