An ancient split of germline and somatic stem cell lineages in Hydra
Nishimiya-Fujisawa, C.; Petersen, H.; Koubkova-Yu, T. C.-T.; Noda, C.; Shigenobu, S.; Bageritz, J.; Fujisawa, T.; Simakov, O.; Kobayashi, S.; Holstein, T. W.
Show abstract
In many animals, germ cell segregation occurs during early embryogenesis to protect the genome, but its origin in basal metazoans is controversial. Here, we show in the freshwater polyp Hydra by clonal analysis and transgenic animals that interstitial stem cells comprise two separate stem cell populations, i.e., germline and multipotent somatic stem cells. We isolated genetically labelled stem cells for a global transcriptome study and discovered a broad set of germline-specific/enriched genes including Prdm9, Pax5, Dmrt1. In an alternative splicing analysis, we identified many genes with germline-specific isoforms; among them, male-specific isoforms of Dmrt1 and Snf5. The somatic interstitial stem cell lineage was characterized by numerous neuronal control genes like Neurog. But all stem cells in Hydra also share a core of stemness genes that has its roots in unicellular eukaryotes. This suggests an evolutionary scenario in which, at the emergence of animal multicellularity, there was an early split into a stable germline and different somatic stem cell lineages.
Matching journals
The top 2 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Pseudotime analysis reveals novel regulatory factors for multigenic onset and monogenic transition of odorant receptor expression 96%
- Analysis of ovarian transcriptomes reveals thousands of novel genes in the insect vector Rhodnius prolixus 94%
- Transcriptomes of Electrophysiologically Recorded Dbx1-derived Inspiratory Neurons of the preBötzinger Complex in Neonatal Mice 94%
Similar papers in this journal
- Spatially resolved cell atlas of the teleost telencephalon and deep homology of the vertebrate forebrain 96%
- Whole-genome sequence analysis unveils different origins of European and Asiatic mouflon and domestication-related genes in sheep 95%
- Starvation Decreases Immunity and Immune Regulatory Factor NF-κB in the Starlet Sea Anemone Nematostella vectensis 94%
Similar papers in this journal
- Comparing the impact of sample multiplexing approaches for single-cell RNA-sequencing on downstream analysis using cerebellar organoids 95%
- Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis 94%
- Giant genome of the vampire squid reveals the derived state of modern octopod karyotypes 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.